Applications of CHyMErA
CHyMErA represents an efficient and versatile system for the combinatorial perturbation of genetic sites in mammalian cells. The Cas9 and Cas12a guides encoded within a hgRNA allow the programmed targeting of the two Cas nucleases to independent genomic sites.
Application Type:
- Dual-Targeting of Single Genes
- Genetic Interaction Mapping
- Higher-Order Multiplexing
- Genetic Segment Deletion
- Genetic Element Deletion
- Non-Coding RNA Deletion
Increased editing efficiency through dual-targeting of single genes.
Dual-Targeting of Single Gene
Dual-targeting diagram placeholder